The destruction of Scheduled medicines and substances may only take place in accordance with the Medicines and Related Substances Act (Act 101 of 1965) and other applicable legislation.

Regulation 27 of the General Regulations published under the Medicines and Related Substances Act (Act 101 of 1965) states that no medicines may be disposed of into municipal sewerage systems and that the destruction or disposal of medicine or scheduled substances must be conducted in such a manner as to ensure that they are not retrievable.

In addition, pharmacists should not dispose of medicine in refuse that may be destined for landfill or municipal refuse sites.