This document provides information and instructions on how to present the required information when communicating the SEP adjustment (SEPA) for medicines for 2019 in terms of Section 22G of Medicines and Related Substances Act (101 of 1965) as amended, and Regulation 8 of the Regulations Relating to a Transparent Pricing System for Medicines and Scheduled Substances. Failure to comply with any of the requirements and instructions in this document will result in the submission being considered incomplete. Incomplete submissions shall be regarded as ineligible for processing on the basis on non compliance.